About

Tissue engineering is a high impact area that contains a rich variety of problems ranging from the bulk-scale mechanics at the organ- and tissue-levels, down to the cell- and molecular-scales of systems biology. The Engineered Tissue Multiscale Mechanics & Modeling (ETM3) Laboratory aims to develop highly-integrative experimental-computational approaches for cardiovascular tissue engineering, in particular, for small-caliber engineered tissue vascular grafts for coronary artery bypass surgery and epicardial restraint patches for myocardium support after infarction.

The ETM3 research approach is based on 3 interconnected components:

• theoretical advancement and model development of dense connective tissue formation
• computational modeling and in silico simulation at multiple scales (cellular-, tissue-, and implant-level)
• pinpointed experimental research for material characterization and model validation.

To complement tissue engineering technology development, alleviate the over-reliance on inefficient empiricism, and relieve critical barriers to its progress, the research program of the ETM3 Laboratory aims to:

• improve mechanistic understanding and help hypothesis formulation
• complement empirical trial-and-error approaches
• provide cost-effective methods for in silico optimization of processes and product design.